HORMONAL THERAPY

 

HORMONAL THERAPY

Used in most patients whose cancer is estrogen and/or progesterone receptors positive meaning the cancer is fed by the female hormones.

Classes of Drugs:

Selective Estrogen Receptor Moderator (SERM)

  • Works by blocking the estrogen/progesterone receptors on the breast cancer cell surface. This deprives the cancer cell of hormones which it needs to grow.
  • Work in all patients regardless of their menopausal status.
  • Generic Name(s): Tamoxifen (taken for 5 -10 years), Toremifene is another rarely used option.
  • Can be used in all stages of breast cancer (1, 2, 3, and 4)

Side Effects:

    • Blood clots
    • Uterine cancer
    • Hot flashes
    • Vision changes

Aromatase Inhibitors (AI)

  • Works by inhibiting the enzyme aromatase which makes estrogen.
  • Work only in patients who are fully post-menopausal.
  • Generic Name(s): Anastrazole, Letrozole, and Exemestane

Side Effects:

    • Hot flashes
    • Joint/muscles pains
    • Mild bone loss

Selective Estrogen Receptor Down-regulator (SERD)

  • Works in patients by down-regulating the estrogen receptors on cancer cells.
  • Approved in patients who have stage 4 breast cancer and are post-menopausal.
  • Administered as a monthly injection.
  • Generic Name(s): Fulvestrant

Side Effects:

    • Injection site pain
    • Joint/muscle aches
    • Elevation of liver tests
    • Hot flashes
Dr. Chris Charlton

Dr. Chris Charlton

Dr. Chris was born in Europe but has lived in the US for many years. He attended college both in Europe and the US and completed medical school at the University of Texas. Residency and fellowship in oncology was completed at Baylor. Read More...
Dr. Chris Charlton

Dr. Chris Charlton

Dr. Chris Charlton

Dr. Chris Charlton

Dr. Chris Charlton

Dr. Chris Charlton

Dr. Chris Charlton

Dr. Chris Charlton